Could mouthwash be effective against coronavirus?

17 November 2020

Preliminary results from a study conducted by scientists at Cardiff University have indicated that some mouthwashes can eliminate coronavirus in saliva in 30 seconds.

Preliminary results from a study conducted by scientists at Cardiff University have indicated that some mouthwashes can eliminate coronavirus in saliva in 30 seconds.

The report states:

The ability of widely-available mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting a 5-log10 reduction in infectivity, under conditions mimicking the naso/oropharynx. During a 30 second exposure, two rinses containing cetylpyridinium chloride and a third with ethanol/ethyl lauroyl arginate eliminated live virus to EN14476 standards (>4-log10 reduction), while others with ethanol/essential oils and povidone-iodine (PVP-I) eliminated virus by 2-3-log10. Chlorhexidine or ethanol alone had little or no ability to inactivate virus in this assay. Studies are warranted to determine whether these formulations can inactivate virus in the human oropharynx in vivo, and whether this might impact transmission.

However, the scientists behind the study have cautioned against hailing mouthwash as a cure-all; the study has not been peer reviewed yet and there is no evidence that mouthwash can be used as a treatment for Covid-19, as it doesn't reach the respiratory tract or lungs.

Dr Richard Stanton, lead author on the study and a reader in virology at Cardiff University, said, “This study adds to the emerging literature that several commonly available mouthwashes designed to fight gum disease can also inactivate the SARS-CoV-2 coronavirus (and other related coronaviruses) when tested in the laboratory under conditions that are designed to mimic the oral/nasal cavity in a test tube.

“This study is not yet peer reviewed and published which means it has not yet been scrutinised by other scientists as is the usual process with academic research. It has now been submitted for publication in a journal.

“It is notable that coronaviruses are far more amenable to disruption than many other viruses and bacteria due to the presence of a viral lipid envelope. Studies to see whether the approach can inactivate the virus in humans are ongoing.

“In the human throat, the virus is being produced constantly, so if there is an effect it will be important to see how long it lasts for and whether this could help reduce transmission, for example in dental investigations, mouth/throat examinations by GPs, or short-term contacts with vulnerable patients or other individuals.

“People should continue to follow the preventive measures issued by the UK government, including washing hands frequently and maintaining social distance. We would encourage people to always use mouthwash safely and as per the manufacturer’s guidelines.”

View the report here.