Following a letter to all of its patients, Taverham Dental Health Clinic announced it will cease NHS treatment for adults and children from 2024.
The practice claimed that "rising costs" due to "chronic lack of investment in NHS dentistry by successive governments" has meant that it is unable to “provide the level of dental care you have come to expect and remain a viable business".
NHS checkups after November 30 have been cancelled, and patients have been offered a membership plan.
Speaking to Norwhich Evening News, Stuart Clancy, county councillor for Taverham, called the announcement a “major blow” for the area.
Stuart added, "A disproportionate number of clinics in Norfolk have been affected by the privatisation of healthcare.
"I don't think the NHS contract is good enough. And unfortunately, there is no short-term fix. I am seeking a meeting with the clinic and Integrated Care Board to understand the situation further.
"In the medium term, a new dental school at the University of East Anglia will help, and I am also pushing for more dental provision in Taverham. But I am fully aware this does not help people with toothache right now."
Mark Jones, a campaigner for Toothless in Norfolk, said, “Families are left to 'go private' and pay outrageous fees that they cannot afford, turn to do-it-yourself dentistry at home, or live in fear that their family's oral health will deteriorate to the point where they must be admitted to the hospital.
"The dental crisis in Norfolk is not going away anytime soon, no matter how many new dental training school announcements or NHS Norfolk and Waveney ICB statements are made.
"Immediate action is required, including significant financial support and a comprehensive revision of the contracts."